Pregnyl

International name:
Chorionic Gonadotropin (Gonadotrophin chorionic)

Group Affiliation:
Luteinizing tool

Description of the active substance (INN):
Chorionic gonadotropin

Dosage form:
lyophilized for solution for intramuscular injection

Pharmacological Effects:
Hormones secreted from the urine of pregnant women. Renders the luteinizing and follicle-stimulating action. Stimulates the synthesis of sex hormones in the ovaries and testes, ovulation, spermatogenesis, provides the function of the corpus lutein, stimulates sexual organs and secondary sexual characteristics.

Indications:
Hypo function of sexual glands (due to impaired activity of the hypothalamus and pituitary gland). Women: dysmenorrhea, ovarian dysfunction, anovulatory infertility, corpus luteum insufficiency (in the presence of ovarian estrogen), "overstimulation" during assisted reproductive techniques, habitual miscarriage, threatening spontaneous miscarriage.For men: genetic disorders: testicular hypoplasia, cryptorchidism; adiposogenital syndrome, pituitary dwarfism, sexual infantilism.

Contraindications:
Hypersensitivity, ovarian cancer, pituitary tumor, androgen-dependent tumors, hypothyroidism, adrenal insufficiency, hyperprolactinemia, gonadal dysgenesis, early menopause, tubal occlusion, thrombophlebitis, period laktatsii.C caution. Adolescence, ischemic heart disease, hypertension, chronic renal failure, asthma, migraine.

Side effects:
Local reactions (pain at the injection site, flushing), headache, fatigue, irritability, anxiety, depression, allergic reactions, suppression of gonadotropic pituitary function. In women, the combined treatment of infertility - ovarian hyper stimulation syndrome (ovarian cyst with the danger of rupture, the appearance of fluid in the abdominal and chest cavity). Men - fluid retention, swelling, increased sensitivity of nipples breast, gynecomastia, an increase in testicle in the inguinal canal (for cryptorchidism).

Dosage and administration:
V / m. Women for ovulation induction - 10.5 thousand m simultaneously, to stimulate the function of the corpus luteu. For the implementation of "superovulation" in the course of assisted reproductive events - up to 10 thousand m once after the induction of growth of multiple follicles, which reach as a result of stimulation of the established pattern. Fence eggs produced by 34-36 h after injection. With the introduction of habitual miscarriage begin immediately after diagnosis of pregnancy (but not later than 8 weeks) and continued until 14 weeks of gestation, inclusive: 1 day - 10 thousand m, followed by 5 thousand m 2 times a week. With the threat of spontaneous abortion (if the symptoms appeared in the first 8 weeks of pregnancy) - 10 thousand m initially, then to 5 thousand m 2 times a week to 14 weeks of gestation, inclusive. At a delay of pubertal development in boys - for 3-5 thousand m once a week for at least 3 months. For Men - 0.5-2 th.m 1 time a day 2-3 times a week for 1.5-3 months. When hypogonadotrophic hypogonadism - 1.5-6 thousand m (in combination with menotropinami) 1 times a week. In order differential diagnosis of cryptorchidism and hypogonadotrophic hypogonadism - a single dose, 5 tys.ME. If cryptorchidism: the age of 6 years - 0.5-1 thousand m 2 times a week for 6 weeks, 6 years old - 1.5 thousand m 2 times a week for 6 weeks. In idiopathic oligospermia normogonadotropic - 5 thousand m weekly for 3 months with menotropinami. If oligospermia and astenospermii caused a relative androgen deficiency - 2.5 thousand m every 5 days or 10 thousand m 1 every 2 weeks for 3 months.

Special instructions:
Men ineffective at high FSH. Prolonged administration may lead to the formation of antibodies to the drug. Increases the likelihood of multiple pregnancy. Possible erroneous results when applying the test for determining pregnancy during drug treatment and within 7 days after withdrawal.

Description of the drug pregnyl not intended to assign the treatment without a doctor.